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Quetiapine caused a dose-related increase in pigment deposition in thyroid gland in rat poisoning studies which were 4 weeks in period or longer as well as in a mouse 2-year carcinogenicity research. Dosages were 10 to 250 mg/kg in rats as well as 75 to 750 mg/kg in mice; these doses are 0.1-3, as well as 0.1-4.5 times the optimum recommended human dosage (MRHD) of 800 mg/day on mg/m2 physical body surface location, respectively. Pigment deposition was revealed to be permanent in rats. The identification of the pigment can not be identified, yet was located to be co-localized with quetiapine in thyroid glandular follicular epithelial cells. The functional effects and also the significance of this finding to human threat are unknown.



In dogs receiving quetiapine for 6 or 12 months, but except 1 month, focal triangular cataracts happened at the junction of posterior sutures in the outer cortex of the lens at a dose of 100 mg/kg, or 4 times the MRHD of 800 mg/day on mg/m2 body surface location. This finding might be because of restraint of cholesterol biosynthesis by quetiapine. Quetiapine created a dose-related reduction in plasma cholesterol levels in repeat-dose canine as well as monkey research studies; nonetheless, there was no correlation between plasma cholesterol and the existence of cataracts in individual dogs. The look of delta-8-cholestanol in plasma follows restraint of a late phase in cholesterol levels biosynthesis in these species. There additionally was a 25 % decrease in cholesterol material of the external cortex of the lens observed in a special research in quetiapine dealt with women dogs. Drug-related cataracts have actually not been viewed in other types; nonetheless, in a 1-year research in monkeys, a striated appearance of the anterior lens surface area was identified in 2/7 girls at a dose of 225 mg/kg or 5.5 times the MRHD of 800 mg/day on mg/m2 body surface location.

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